When Andrew Ryan took over Fontaine Futuristics, he discovered the existence of the children. įrank Fontaine created his Little Sister's Orphanage in Apollo Square and other locations as a front to exploit the children as his supply of hosts for ADAM production.
They still maintained many of the ordinary characteristics of small children: laughing, playing, smiling, and singing. Although Tenenbaum hoped to be able to keep the children in a vegetative state, it was found they had to be fully functional to produce the ADAM. Young girls, nicknamed "Little Sisters" following the implantation process, were found to be the only viable hosts. Brigid Tenenbaum developed a procedure whereby a Sea Slug was implanted in a human host's stomach, and a symbiotic interaction between host and slug yielded up to thirty times the quantity of usable ADAM. The ADAM-producing Sea Slugs did not naturally produce a large enough quantity for serious research and commercial exploitation. ADAM is excreted by unique Sea Slugs found near Rapture.